Predictive factors of clinical assays on hydroxychloroquine for COVID-19 mortality during the first year of the pandemic: A meta-synthesis

Background: The COVID-19 pandemic led to a violent debate about the efficacy of repurposed drug hydroxychloroquine (HCQ) and new broad-spectrum antiviral (remdesivir) randomized controlled trials (RCTs) observational studies. To understand conflicting results in literature, we performed meta-synthesis determine whether intrinsic qualitative criteria within studies may predict apparent or ineffectiveness HCQ remdesivir. Methodology: Predictive were identified through critical review assessing remdesivir for mortality from March November 2020. Multiple correspondence analysis, comparative meta-analysis, predictive value used explore identify associated with study outcomes. Results: Among 61 included studies, potential conflict interest, detailed therapeutic protocol, toxic treatment (overdose use contraindicated patients), known centers doctors, private data computing company most direction effect All 18 evaluating reporting protocol without interest Pro. Potential was perfect predictor efficacy. RCTs inefficacy interest. validated allowed classification 10 additional studies.Conclusion: In on COVID-19, major biases predicting conclusions are not methodology nor but absence medical expertise. thorough search declared undeclared direct indirect expertise should be quality evaluation future beyond. A checklist only also is proposed.